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FAQs ABOUT PREMARIN VAGINAL

What PREMARIN VAGINAL is used for?

PREMARIN VAGINAL is used to manage vaginal itching, inflammation, dryness, and vaginal thinning caused due to estrogen deficiency (atrophic vaginitis). It can also be used to manage itching and inflammation of vulva and other parts of the genital area such as labia minora, clitoris and vaginal orifice (kraurosis vulvae). It also helps in manageing moderate to severe dyspareunia (genital pain during sexual intercourse) that occurs due to menopause.

Who should not use PREMARIN VAGINAL?

PREMARIN VAGINAL is not recommended for use in patients allergic to Conjugated estrogens. It is also not suitable for use in patients having unusual vaginal bleeding, breast or uterine cancer, blood clot in legs (deep venous thrombosis) or lungs (pulmonary embolism), bleeding disorder or heart problems. PREMARIN VAGINAL should not be used in pregnant or breastfeeding without consulting your doctor.

How to use PREMARIN VAGINAL?

Apply PREMARIN VAGINAL as directed by your physician. It should be used only in and around the vagina or the genital area. PREMARIN VAGINAL comes in a tube along with an applicator. Use the applicator for applying the medicine. Gently squeeze the sufficient medicine from the tube into the applicator. Lie down on your back or in any comfortable position. Gently insert the applicator into the vagina and press the plunger downwards to release the medicine in the vagina. Remove the applicator from the vagina after application. If you want to apply PREMARIN VAGINAL to the external parts of vagina, take the required quantity of PREMARIN VAGINAL and apply it at the required sites of the genital area.

What are the side effects of PREMARIN VAGINAL?

The most common side effects of applying PREMARIN VAGINAL are stomach pain, back pain, breast pain or tenderness, headache, vaginal infection, or vaginal discharge. Consult your doctor if any of these side effect worsens. Also, inform your doctor if you experience any changes in your breast such as breast pain, tenderness, discharge from the nipple, or lump growth in the breasts, heavy menstrual bleeding, pain, swelling, redness of the legs, sudden chest pain or difficulty in breathing after using PREMARIN VAGINAL.

Can PREMARIN VAGINAL cause cancer?

Yes. Research has that shown that prolonged use of PREMARIN VAGINAL may lead to breast cancer or uterine cancer. To avoid this, your doctor will constantly monitor your health condition through periodic blood tests and ultrasounds (breast examination). However, inform your doctor immediately if you experience any unusual symptoms such as severe breast pain or tenderness, purplish discoloration of breasts, discharge from nipples, pelvic pain or abnormal vaginal bleeding.

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What are the side effects of taking PREMARIN VAGINAL?

Some of the side effects of taking PREMARIN VAGINAL are stomach pain, back pain, breast pain or tenderness, headache, vaginal infection, or vaginal discharge.

Can PREMARIN VAGINAL beION cause chest pain?

Yes, PREMARIN VAGINAL contains Conjugated estrogens, which is a type of estrogens that works as a first line of action for treating itching, pain and inflammation of the stomach, vagina and endometrium.

What are the precautions of taking PREMARIN VAGINAL?

Take PREMARIN VAGINAL only if it is required to do in near full effect. Do not skip the medication even if it is being applied at the same time as the next application. Use for long repeated application(s). Follow the doctor's instructions exactly. Consult your doctor if you are sensitive to the application of the medicine.

Can PREMARIN VAGINALUS cause breast or uterine cancer?

PREMARIN VAGINAL contains Conjugated estrogens, which is a type of estrogens that works as a first line of action for treating itching, pain and inflammation of the stomach, vagina and endometrium.

Pre-treatment with estrogensto reduce the risk of miscarriage, Premarin-conjugated estrogens (E4) and estradiol, are two drugs that can be used to treat menopausal symptoms (such as hot flashes). Estrogens are used to treat female pattern hair loss (androgenetic alopecia), in women with female pattern hair loss and other conditions associated with hormonal imbalances. Premarin-conjugated estrogens are also used to treat androgen-dependent prostate cancer, and can help with hair loss and benign prostatic hyperplasia (BPH) in women who have undergone surgery. When estrogen levels are low, estrogens help maintain hair in areas of thinning. Premarin is a progestin-only drug; estrogens have no effect on the body’s ability to produce estrogen, but can lower the levels of estrogen in the body.

Benefits of Premarin

• Estrogens can lower the levels of estrogen in the body and reduce the chances of cancer.
• Progestin-only drugs, such as estrogens, help keep estrogen levels low, so that estrogen levels can be restored.
• Premarin is a non-hormonal, non-steroidal hormone that works by replacing estrogen that had been naturally produced in the body. Estrogens can also help prevent or treat hair loss, such as androgens.
• Estrogens, such as estrogens and estrogens-alone, may not be necessary for menopausal symptoms.
• Premarin can be taken for a variety of purposes, including:

Dosage

The dose of Premarin is usually taken once daily, but your doctor may increase your dosage. Your doctor can help you determine which dosage is most appropriate for you and your symptoms.

Side effects

• Hot flashes are common with Premarin.
• Mood changes may occur. It is important to talk to your doctor about your symptoms.
• It is important to take Premarin with food to reduce stomach upset and decrease appetite.
• The risk of breast cancer increases with higher doses.
• You should discuss your symptoms with your doctor before you take Premarin.

Storage

Keep Premarin-conjugated estrogens tablets and oral contraceptive tablets in their original packaging and tightly closed. Store the Premarin tablets and the contraceptive tablets in their original packaging and tightly closed. Do not open the pack to take more pills.

Precautions

• If you are allergic to any of the ingredients in Premarin, you should not use this drug.
• Avoid taking estrogen pills if you are experiencing a high level of estrogen in your body. Premarin has a strong affinity for estrogen receptors and can reduce estrogen levels.
• Women with breast cancer or cancer of the breast or uterus should use Premarin, with or without a prescription.
• You should not take estrogens if you are pregnant or are planning to become pregnant.
• If you have severe acne or a painful rash, you should stop taking estrogens or stop using Premarin and discuss your treatment options.
• If you have liver problems, you may need to use Premarin with caution. Talk to your doctor about the risks and benefits of using Premarin.
• Premarin tablets may cause breast enlargement. This is not a complete warning. Consult your doctor before using Premarin.

Possible side effects

• Breast cancer may occur in men with low levels of estrogen.
• Women with a low level of estrogen may be at risk of developing breast cancer.

• If you are taking Premarin, do not take any other drug or treatment.
• If you have a history of liver problems, you should discuss your treatment options with your doctor.
• If you have breast or uterine cancer, you should discuss your treatment with your doctor.

Premarin 0.625mg tablet is an hormone replacement therapy contains the active ingredient Conjugate Estrogen. It is an a female sex hormone that belongs to the family known as estrogens. It is used to treat menopausal symptoms in and around the vagina (such as itching, dryness, burning, and pain). It is used to treat painful intercourse caused by menopausal changes of the vagina.

Do not take Premarin 0.625mg tablet if you are allergic to Conjugate Estrogen, or any of its ingredients. Do not initiate the use of this medicine if you experience unusual vaginal bleeding, have a history of certain cancers, including breast or uterine cancer, have had a stroke or heart attack, suffer from blood clot issues, have liver problems, a diagnosed bleeding disorder. Consult your healthcare provider if you have or have had cancer before considering the use of this medicine. If you suspect pregnancy, avoid using the tablet.

Inform your doctor about any unusual vaginal bleeding, as postmenopausal vaginal bleeding could indicate uterine cancer. Share your complete medical history, especially conditions like asthma, epilepsy, diabetes, migraine, endometriosis, lupus, heart, liver, thyroid, kidney issues, or elevated blood calcium levels. Disclose all medications, including prescriptions, non-prescriptions, vitamins, and herbs, as interactions with Premarin 0.625mg tablet are possible. If you are planning for surgery or bedrest, consult your healthcare provider, and if breastfeeding, be aware that the tablet's estrogen hormones may pass into breast milk. Also, notify your physician about any gallbladder disease risk, as estrogens can elevate this risk. Discontinue estrogen use if severe hypercalcemia, vision loss, extreme hypertriglyceridemia, or cholestatic jaundice arises. For women on thyroid replacement therapy, closely monitor thyroid function.

Precautions for Premarin 0.625mg tablet:

• Monitor for ovulatory dysfunction. In women on thyroid replacement therapy, administer estrogens at different dosages to minimize estrogenic effects.
• Avoid small doses of estrogens, as they can increase the risk of hypercalcemia.
• Avoid excessive contact with broken tablets. Contact your healthcare provider if you develop symptoms like irritation at the application site, painful/difficult urination, or symptoms of hypercalcemia.
• Avoid broken tablets during menopause. In certain cases, estrogens can cause acute hypercalcemia, which can progress to hypercalcemia or serum calcium elevation, coma. Use prophylactically, especially during treatment with thyroid supplementation, as osteoporosis, bone loss, or decreased bone mineral density occur in women with osteoporosis who are eligible for thyroid supplementation, may also benefit from prophylaxis against osteoporosis.

For treatment instructions and dosages

1. To apply Premarin 0.625mg tablet, simply write:

   Age: 18-44 years.

2. Use: In accordance with United States Food and Drug Administration/Canadian Drug Application, Premarin 0.625mg tablet should not be used during pregnancy unless considered medically necessary. In women who are pregnant, the tablet should not be used during pregnancy unless considered medically necessary. In women who are breast feeding, the tablet should not be used unless considered medically necessary. In women who are breast-feeding, the tablet should not be used unless considered medically necessary. Consult your healthcare provider if you have or have had cancer, or any other hormonal therapy, before considering the use of this medicine. If you suspect pregnancy, contact your healthcare provider immediately.
3. Dosage: In accordance with United States Food and Drug Administration/Canadian Drug Application, Premarin 0.625mg tablet should not be used during pregnancy unless considered medically necessary. In women who are pregnant, the tablet should not be used unless considered medically necessary.
4. Pregnancy: If you are pregnant, consult your healthcare provider or a licensed physician who can discuss your medical history, along with potential risks, before using Premarin 0.625mg tablet. Premarin 0.625mg tablet should not be used during pregnancy unless considered medically necessary.

Premarin (Conjugated Estrogens)

Conjugated estrogen is a mixture of two conjugated hormones: estrogen and progesterone. Estrogen and progesterone are produced primarily by the adrenal gland. Progesterone is produced mainly from the pituitary gland in the brain, adrenal glands, and adrenal glands of the female reproductive system. When a woman is pregnant, she produces progesterone and then estradiol, which are both produced by the pituitary gland. Estrogen and progesterone are excreted in the breast milk. These hormones help to prevent the development of pre-existing,,,, and other conditions caused by the female sex hormone estrogen. Conjugated estrogens are used to treat symptoms of low sex drive, including, but not limited to, breast cancer, irregular bleeding, abnormal uterine bleeding, and vaginal bleeding. The drug estradiol is used to treat, a condition in which there is increased blood flow to the brain and spinal cord to cause a sensation of numbness or tingling in the arms, face, lips, or mouth.

How to Use Premarin Vaginal Cream (Premarin Vaginal Cream 0.3%):

Premarin Vaginal Cream is available in two strengths (0.3% and 0.05%).

Premarin Vaginal Cream is used to treat the symptoms of menopause such as:

• Breast Tenderness in Women(such as hot flashes, vaginal dryness)
• Vaginal Irritation(such as irritation at the vaginal opening)
• Breast Tenderness(redness, pain, irritation)

Premarin Vaginal Cream should be applied to the skin five times a day

Premarin Vaginal Cream is only used to reduce the risk of unwanted pregnancy-related symptoms, such as low vaginal discharge, thinning of the lining of the uterus, and a thinning of the vaginal lining.

Premarin Vaginal Cream may be used in women of childbearing age if the woman is under a doctor's care for a medical condition, or for a health condition, such as breast cancer.

Premarin Vaginal Cream may be used in women of childbearing age if the woman is under a doctor's care for a medical condition, or for a health condition, such as breast cancer

Premarin Vaginal Cream is used in women of childbearing age if the woman is under a doctor's care for a medical condition, or for a health condition, such as breast cancer

Possible Side Effects of Premarin Vaginal Cream (Premarin Vaginal Cream 0.